Titans vs. Broncos Predictions, Odds, & Best Bets: Week 1

In Week 1 of the NFL season, rookie quarterback and No. 1 overall pick in the 2025 NFL Draft Cam Ward will get his first taste of the pros. 

The Titans and Broncos haven’t played since 2022. The Titans won that game 17-10. 

Checking out the NFL futures odds, the Broncos are +4000 to win the Super Bowl, whereas the Titans are tied for the second-worst odds at +20000.

See my best bet for this matchup using football betting odds from the BetMGM sportsbook below. 

Titans vs. Broncos Odds

• Titans spread: +7.5 (-110)
• Broncos spread: -7.5 (-110)
• Titans moneyline: +280
• Broncos moneyline: -350
• Total: 41.5 (-110/-110)

Titans vs. Broncos Predictions & Best Bets

Making your first start in the NFL is always a tough battle, but the Denver Broncos at Mile High in Week 1? Ouch. 

Yes, that’s the fate of No. 1 overall draft pick Cam Ward. 

The team has some talent around him, adding Dan Moore and Kevin Zeitler to the offensive line and Van Jefferson, Tyler Lockett, Elic Ayomanor, Chimere Dike, and Xavier Restrepo at wide receiver. 

Still, this Broncos defence in your first NFL start is going to be rough, to say the least. 

The secondary boasts the reigning NFL Defensive Player of the Year, Patrick Surtain II, and they have only added to it, selecting Jahdae Barron in the first round. 

The Broncos’ offence will be more dynamic as well after signing tight end Evan Engram and drafting RJ Harvey to be what I’d presume is their lead back. 

I’m siding with the Broncos here. 

Welcome to the NFL, Mr. Ward. 

What’s the All-Time Head-to-Head Record Between the Broncos and Titans?

The Titans lead the all-time head-to-head series at 25-18-1. 

What’s the Head-to-Head Record Between the Broncos and Titans in the Playoffs?

These teams have met three times in the postseason. The Broncos are 2-1. 

What’s the Longest Winning Streak Between the Broncos and Titans?

The longest winning streak between the Broncos and Titans belongs to the Broncos. They won three games from 2004 to 2010.

When Was the Last Game Between the Broncos and Titans?

The last game between the Broncos and Titans was on November 13, 2022. The Titans won 17-10. 

What’s the Largest Margin of Victory Between the Broncos and Titans?

The largest margin of victory between the Titans and the Broncos came on November 5, 1961, when the Titans beat the Broncos by 41 points. The final score was 55-14.