Bills vs. Jaguars Odds & Predictions: AFC Wild Card

After resting some starters, but still beating the New York Jets 35-8, the Buffalo Bills locked up the No. 6 seed in the AFC and hit the road to take on the Jacksonville Jaguars. 

Heading into the Wild Card round, the Bills’ odds to win the Super Bowl are +1000, tied for fifth in the NFL along with the New England Patriots. 

Examining the NFL spreads this week, the Bills are one of three road favourites. 

Below, I’ll provide a prediction for this game using odds from the BetMGM sportsbook, where football betting is available throughout the postseason.

Bills vs. Jaguars Odds

• Bills spread: -1.5 (-110)
• Jaguars spread: +1.5 (-110)
• Bills moneyline: -120
• Jaguars moneyline: +100
• Total: 52.5 (-110/-110)

Bills vs. Jaguars Predictions

Of all the matchups in the Wild Card round, this is the worst for the Bills. 

While they’re favoured by 1.5 points on the road, there’s a real chance they lose this game. 

Related: How to Watch Bills vs. Jaguars AFC Wild Card in Canada

The Jaguars have the best run defence in the NFL, holding teams to 85.6 yards per game. That number is at 82.3 yards over their last three, and in Week 18, they surrendered only 77. 

This will be a classic strength-on-strength matchup as the Bills average 159.6 rushing yards (first) and 32.2 rushing attempts (first) per game. 

Additionally, in the pass game, the Jaguars primarily play Cover-3 and Cover-6, and over his last five games (Weeks 13 to 17; he didn’t play in Week 18), Allen has one interception and no touchdown passes on 63 dropbacks against those coverages.

I’ll never count out Bills quarterback Josh Allen, but he has a tall hill to climb.

With that said, I predict the Jaguars will cover the spread at +1.5. 

What’s the All-Time Head-to-Head Record Between the Bills and Jaguars?

The all-time head-to-head record between the Bills and Jaguars is 10-10. 

What’s the Head-to-Head Record Between the Bills and Jaguars in the Playoffs?

The Bills are 0-2 in the playoffs against the Jaguars. 

What’s the Longest Winning Streak Between the Bills and the Jaguars?

The longest winning streak between the Bills and Jaguars is three games. The Bills won three straight from 1998 to 2003. 

When Was the Last Game Between the Bills and the Jaguars?

The last game between the Bills and Jaguars was played on Sept. 23, 2024. The Bills won 47-10. 

What’s the Largest Margin of Victory Between the Bills and the Jaguars?

The largest margin of victory between the Bills and Jaguars is 37 points. The Bills beat the Jaguars 47-10 in 2024.